南粤风采36选7走势图

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分子相互作用技术平台

南粤风采36选7走势图GENGXINSHIJIAN:2019-04-08

简要描述:

南粤风采36选7走势图ForteBioGONGSIDEOctetFENZI XIANGHUZUOYONGJISHUPINGTAIBAOKUOYIQI、SHENGWUCHUANGANQIHEXIANGYINGSHIJIHE,SHIYIZHONGMIANBIAOJIDE,SHISHIJIANCEDEXIANJINJISHU,ZHUYAOYONGYUSHENGWUFENZIJIANXIANGHUZUOYONGDONGLIXUECANSHUYIJIDANBAINONGDUDECEDING。

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Octet 分子相互作用技术平台

ForteBio公司的Octet分子 相互作用技术平台包括仪器、生物传感器和相应试剂盒,是一种免标记的,实时监测的先进技术,主要用于生物分子间相互作用动力学参数以及蛋白浓度的测定。该平台通过浸试即读的监测方式(Dip and ReadTM)来提高了检测通量,简单易学并有利于优化操作流程,使得用户能在数分钟内就可以获得大量的可靠数据。在很多的应用领域中,这种技术平台可以作为ELISA,HPLC以及SPR技术分析方法的有效替代手段。
 

Octet系统的蛋白浓度定量和生物分子间相互作用动力学参数测定(Ka,Kd和KD南粤风采36选7走势图),可以为早期研发过程提供重要的信息;同时,它的高通量优点可以大大节省研发的时间。它不仅可以运用于早期的研发和筛选以及晚期的临床试验,还可以用于生产监控和质量监控。正是因为Octet平台不需要微流体控制系统,所以可以适用于粗样品检测;它的高通量特性使得其适用于抗体和化合物库的筛选。

 

BLI非标记检测能跟踪检测溶液中分子与生物传感器之间的结合,解离整个过程的变化。同一平台,多种应用:
 

一、Octet 分子相互作用技术平台--在药物开发过程中广泛的应用

基础研究

先导药物的发现和优化

过程控制

生产和QC

临床前研究和临床研究

DONGLIXUECANSHUCEDING

ZAJIAOLIUDONGLIXUESHAIXUAN

KELONGDEXUANZEHEPAIXU

SHENGCHANLIANGDEJIANKONG

JIANYIZHILIAODEDONGLIXUEPINGJIA

XIANGHUZUOYONGJILIYANJIU

SHIJUNTIKUDONGLIXUESHAIXUAN

DANBAIBIAODAJIANKONG

CANLIUWUDECEDING

KANGYAOKANGTIJIANKONG

KUAISUJIANCEFANGFADEJIANLI

KANGYUANBIAOTICEDING

GUOCHENGYOUHUA

CHANPINPICIBIJIAO

YAODAIDONGLIXUEYANJIU

XIAOFENZIHUAHEWUDESHAIXUAN

PEIDUIKANGTISHAIXUAN

SHENGWUHUOXINGPINGGU

SHENGWUHUOXINGCESHI

SHENGWUBIAOJIWUCEDING

 

QINHELIPAIXU

 

WENDINGXINGCESHI

 

 

DANBAIZHIGONGCHENG

 

 

 

 

二、Octet 分子相互作用技术平台--抗体和其他蛋白的定量

南粤风采36选7走势图OctetPINGTAIKEYIDUIKANGTIHEQITADANBAIJINXINGKUAISUNONGDUCEDING,ZHEISHIDEGAIPINGTAIKEYIYONGYUBIAODAKUDESHAIXUAN、SHANGYOUYUXIAYOUDESHENGCHANGUOCHENGKONGZHIHESHENGWUXUEZHILIAOZHONGSHENGWUBIAOJIWUDENONGDUDINGLIANGCEDING。

· CEDINGJIEGUOYUHPLCYOUHENHAODEKEBIXING,JINGMIDUYOUYUELISA。

· 15FENZHONGZUOYOUKEYICEDING96GEYANGPINDENONGDU

· ZHIJIECEDINGDEXINGSHI,BUXUYAOBIAOJIHEQITASHIJI

· BUXUYAOFANSUODECHUNHUAGONGCHENG,KEYIZHIJIECEDINGZHURUPEIYANGSHANGQINGDENGCUYANGPIN

· KEYITIGONGDINGZHIFUWU,GENJUYONGHUXUYAOZHIZUOTESHUDESHENGWUCHUANGANQI


三、Octet 分子相互作用技术平台--更快更准的ELSA测定

南粤风采36选7走势图YUELISAXIANGBI,OctetPINGTAIZIDONGHUACHENGDUGAO,CEDINGDESUDUKUAI,ERQIEKEYIHUODEGENGFENGFUGENGZHUNQUEDESHUJU,KEYIYUNYONGYUYAODAIDONGLIXUEHESHENGWUXUEZHILIAOZHONGSHENGWUBIAOJIWUDECEDING。

南粤风采36选7走势图· GAOLINGMINDUDE2BUFAHE3BUFACEDING

· CEDINGTIAOJIANKEYIZAIJIGEXIAOSHINEIJINXINGYOUHUA

· CESHIKEYIZAI3XIAOSHINEIJIESHU,BUYAOJINXINGGUOYEBAOBEI

南粤风采36选7走势图· QUANZIDONGXITONG,BUXUYAOXIDIBUZHOU,JIESHENGLESHIJIANBINGJIANSHAOLERENWEIWUCHA

南粤风采36选7走势图· SHISHIDEXIANGHUZUOYONGSHUJUBIELISASUOYONGDEZHONGDIANPANDINGFAKEYITIGONGZHURUJIELICHANGSHUDENGGENGDUODEXINXI。

· KEYIJIANCEDAOELISAJIANCEBUDAODEGENGRUODEJIEHE


四、Octet 分子相互作用技术平台--功能筛选及定性分析

OctetXITONGTIGONGLECUNZAIYUCUYANGPINZHONGDEDANKANGHEKANGYUANJIANDEKUAISUDEJIANCEFANGFA。ZHEIYANGKEYIWEIKANGTIYAOWUDESHAIXUAN、GUOCHENGYOUHUAYIJIYIMIAODEYANFAZHONGJINZAOTIGONGZHONGYAODEXINXI,BANGZHANKEHUJINZAOZUOCHUPANDUAN。

· Ka,Kd和K等动力学参数的研究

南粤风采36选7走势图· QINHELICANSHUDECESHIFANWEICONGmMDAOpMJIBIE

南粤风采36选7走势图· KEJIJIANCEXUEQINGHUOZHEXIBAOLIEJIESHANGQINGDENGYANGPIN

南粤风采36选7走势图· KANGYUANBIAOWEIJIANDINGHEPEIDUIKANGTISHAIXUAN-ZAI6GEXIAOSHINEIKEYIZUO34×34GEFANYING

南粤风采36选7走势图· KEYITONGSHICEDING8GE(96KONGBAN)HUOZHE16GEYANGPIN(96KONGBANHUO384KONGBAN)

· KEYICEDINGMODANBAIHEBINGDUKELIDEDONGLIXUECANSHU

 

五、Octet 分子相互作用技术平台--小分子化合物和分子片段筛选

南粤风采36选7走势图OctetXITONGKEYIKUAISUDEJIANCEXIAOFENZIHUAHEWU,SHIXIANCONGHUAXUEBAWUDAOXIANDAOHUAHEWU(hit to lead)DEJIANCE

· 非标记检测大于150Da化合物

· 提供高质量的动力学参数,包括Ka,Kd以及稳态KD

· KUAISUHUAHEWUKUSHAIXUAN——8GEXIAOSHINEIJIANCE1000GEHUAHEWU

南粤风采36选7走势图· BUXUYAOJINXINGRONGJIXIAOZHENG——OctetXITONGKEYINAISHOUGAONONGDUDEDMSO

· DUOGONGNENGDERUANJIANSHIDESHUJUFENXIGENGJIANDAN,GAOTONGLIANGDELIUCHENGGENGJIANJIE

 

Octet 分子相互作用技术平台--技术优势

南粤风采36选7走势图LIANGHAODEXINGNENG——FEICHANGKEKAODI,GAOZHILIANGDESHUJU

· MIANBIAOJI,SHISHIJIANKONG

· JUBEIHPLCDEZHUNQUEXING

· BIELISAGENGHAODEJINGMIDU

· YUSPRHEITCFANGFADEJIANCEDEJIEGUO*

· KEYIJIANCECUYANGPIN,BIRUGAOZHANDUDEYETI,DIRONGJIEDUDEFENXIWU

 

JIANDAN——RONGYIXUEXIHECAOZUO

· 2XIAOSHINEIJIUKEYIZHANGWO

· QUANZIDONGDECAOZUOPINGTAI

南粤风采36选7走势图· WUXUWEILIUKONGXITONG,BUXUYAOZHUANYEDEWEIHUHECAOZUORENYUAN

· ZHONGDUOBUTONGZHONGLEIDESHENGWUCHUANGANQIKEYIMANZUBUTONGDEXUYAO

· ZHIGUANDECAOZUOHEFENXIRUANJIAN

 

KUAISU——GENGKUAIDIZHIDAOJIEGUO,GAOTONGLIANG

南粤风采36选7走势图· DUI96GEYANGPINJINXINGNONGDUJIANCEZHIYAO15FENZHONG

· SHAIXUAN1000ZHONGHUAHEWUZAI6GEXIAOSHINEIWANCHENG

南粤风采36选7走势图· DUOBUFAELISAJIANCEZAI3GEXIAOSHINEIWANCHENG

南粤风采36选7走势图· 96KONGHE384KONGDEJIAYANGXINGSHI

南粤风采36选7走势图· KEYIYUZIDONGHUAGONGZUOZHANJIANRONG

 

南粤风采36选7走势图XIAOLV——GAOXIAODECAOZUOLIUCHENG,BIANYIDECHENGBEN

· ZAISHUXIAOSHINEIJIANLIJIANCEFANGFA

· CUYANGPINBUXUYAOCHUNHUA,KEYIZHIJIEJIANCE

· KUANFANDEJIANCEFANWEI,YANGPINKEYIBUYONGXISHI,ZENGJIAZHUNQUEXING

南粤风采36选7走势图· SHENGWUCHUANGANQIKEYIDUOCIZAISHENG

· FEIPOHUAIXINGYANGPINJIANCE,YANGPINKEYIHUISHOULIYONG

· YANGPINHAOYONGLIANGJIDI

 

Octet家族——*的解决方案

YIQIZHONGLEIHETEXING

 

Octet RED384

Octet QK384

Octet RED96

Octet QKe

Analyte MW(Kinetics)

>150D

>5kD

>150D

>5kD

Channels

16

16

8

8

96-Well Format

384-Well Format

Minimum Assay Volume

40ul

40ul

200ul

200ul*

Plate Positions

2

2

1

1

Biosensor Re-racking

Automation-Friendly

*KEYIGENJUYONGHUXUYAOJIANGJIAYANGTIJIJIANSHAOZHI80-120uL

 

BLI基本原理

南粤风采36选7走势图OctetXITONGSUOYUNYONGDESHENGWUMOGANSHEJISHU,SHIYIZHONGMIANBIAOJIJISHU,SHISHITIGONGGAOTONGLIANGDESHENGWUFENZIXIANGHUZUOYONGXINXI。GAIYIQIFASHEBAIGUANGDAOCHUANGANQIBIAOMIANBINGSHOUJIFANSHEGUANG,BUTONGPINLVDEFANSHEGUANGPUSHOUDAOSHENGWUCHUANGANQIDEGUANGMOCENGHOUDUDEYINGXIANG,YIXIEPINLVDEFANSHEGUANGXINGCHENGLEXIANGZHANGGANSHE(LANSE),ERLINGYIXIESHOUDAOLEXIANGXIAOGANSHE(HONGSE)。ZHEIXIEGANSHEBEIGUANGPUYISUOJIANCEDAO,BINGXINGCHENGYIFUGANSHEGUANGPU,BINGYIGANSHEGUANGPUDEXIANGWEIWEIYIQIANGDU(nm)XIANSHI。YINCI,JIEHEDAOCHUANGANQIBIAOMIANDEFENZIYIDANYOUSHULIANGSHANGDEZENGJIAN,GUANGPUYIBIANHUISHISHIDIJIANCEDAOGANSHE GUANGPUDEWEIYI,ERZHEIZHONGWEIYIZHIJIEFANYINGCHUCHUANGANQIBIAOMIANSHENGWUMODEHOUDU。

SHENGWUMOGANSHEJISHUDEYOUDIAN

南粤风采36选7走势图· KEYIHUOQUSHENGWUFENZIXIANGHUZUOYONGDEGAOZHILIANGDESHUJU

· ZHIJIEZUOYONGDEJIANCEFANGSHI,KEMIANQUBIAOJIHEXINHAOFANGDABUZHOU

· SHISHIJIANKONGKEYIDUIXIANGHUZUOYONGJINXINGDONGLIXUEFENXI

南粤风采36选7走势图· LIANGHAODEFANYINGTEYIXING,JISHIZAICUYANGPINZHONG

· SHIYONGYUFEICHANGGUANGFANDEBUTONGWUZHIFENZI

 

 

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